本季紧随第41季连续制作拍摄，同样在斐济岛取景，同样因为疫情将39天的赛程缩短至26天。选手因为没有看过第41季的相关内容，因此第41季出现的变数像“疯狂密语”等将继续保留，同时又增加了新的变数，这将是又一次新的进化。
Dr. Michelle Oakley, a veterinarian in one of the most rugged environments on Earth. Making house calls in the far reaches of Northern Canada is a daunting task in the least, considering the houses may be separated by hundreds of miles. That challenge doesn't stop Dr. Michelle Oakley from performing her many duties as a veterinarian in one of the most rugged environments on Earth. In addition to running an animal clinic out of her home in Haines Junction, Yukon -- where she lives with husband Shane and their three daughters -- Dr. Oakley also operates a satellite clinic 150 miles away and is the on-call vet for the Yukon Wildlife Preserve, which is about 100 miles from Haines Junction. She also makes house calls, sometimes driving for long stretches through desolate wilderness to check on a patient. This series documents how Dr. Oakley juggles being a full-time vet, wife and mom, and does so with a sense of humor and devotion.
Syfy真人秀节目《Face off》于1月12日播出。参赛者将比拼特效化妆技术。评委是世界顶尖的影视特效设计师和化妆室，参与制作的项目包括《吸血鬼猎人巴菲》、《黑夜传说》、《生化危机3：劫后余生》、《X档案》和《剪刀手爱德华》等。
《聲控鬥室》是一個全方位考驗大家對聲音認知的節目，每一集都會有嘉賓來挑戰主持們大玩聲音遊戲，測試他們有幾細聲，有幾大聲，有幾咁認識「聲」，勝出者就可贏出這場「聲控鬥室」！
一群来自拉丁美洲和西班牙的热辣单身者齐聚在热带天堂，这群年轻人认为这将是他们生命中最具异国情调和最火热的夏天，但转折不期而至。如果想要赢得 10 万美元的大奖，这些喜欢约炮的承诺恐惧症患者全程都不得接吻、亲昵，也不能以任何形式自慰。每僭越一次，奖金就会随之减少。热衷单身的人能建立更深的情感联系吗？还是诱惑太过强烈，让人无法自持？
Tory and Tommy see some serious kaboom action and meet the trained professionals who get to detonate all kinds of things every day.
These are the true stories of American heiresses who travelled to England to marry titled English men in the late 1800s.
